Polymer‐Formulated Nerve Growth Factor Shows Effective Therapeutic Efficacy for Cerebral Microinfarcts
Cerebral microinfarcts represent the most prevalent form of ischemic brain injury in the elderly, particularly among those suffering from dementia, Alzheimer's disease, and vascular risk factors. Despite their commonality, effective treatments have remained elusive. Herein, a novel treatment utilizing a polymer-formulated nerve growth factor capable of crossing the blood-brain barrier is reported, which effectively reduced oxidative stress and neuronal apoptosis, reshaped microglia polarization at infarct sites, and decreased the overall microinfarct burden, leading to notable improvements in behavioral and cognitive functions in a mouse model. This work provides a promising new avenue for the treatment of cerebral microinfarcts and other neurodegenerative diseases.
Authors
- Yunfeng Lu (ORCID: https://orcid.org/0000-0002-8589-0297)
- Huanxing Su (ORCID: https://orcid.org/0000-0003-3254-825X)
- Yu‐Qi Feng (ORCID: https://orcid.org/0000-0003-1107-5385)
- Qihai Gong (ORCID: https://orcid.org/0000-0002-8967-337X)
- Jimin Guo (ORCID: https://orcid.org/0000-0002-8249-1880)
- Dajiang Qin (ORCID: https://orcid.org/0009-0008-2792-3514)
- Yicheng Feng (ORCID: https://orcid.org/0000-0002-4562-5827)
- Lihua Hou (ORCID: https://orcid.org/0000-0001-7366-8974)
- Kunyao Xu (ORCID: https://orcid.org/0009-0002-5086-6884)
- Chaoyong Liu (ORCID: https://orcid.org/0000-0002-0914-687X)
- Meng Qin (ORCID: https://orcid.org/0000-0002-5448-2477)
- Yilong Wang (ORCID: https://orcid.org/0000-0002-7833-9990)
- Mo Yang (ORCID: https://orcid.org/0000-0002-5449-9957)
- Lingli Yan
Institutions
- Zunyi Medical University (CN)
- Capital Medical University (CN)
- University of Macau (MO)
- Sichuan University (CN)
- Beijing Tian Tan Hospital (CN)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1002/adma.202412843
- Citations
- 3
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- State Key Laboratory of Quality Research in Chinese Medicine, University of Macau
- National Key Research and Development Program of China