Single‐cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers
Comparative scRNA-seq analysis reveals significant similarities in genetic, transcriptomicand immune profiles between MPLCs and SPLCs. Identification of a unique immunosuppressive F13A1+ macrophage subtype, preferentially enriched in MPLCs, linked to immune evasion and tumourprogression. SPP1-CD44/CCL13-ACKR1 interactions are crucial in MPLC tumour microenvironment, indicating potential targets for therapeutic intervention.
Authors
- Lishen Zhang (ORCID: https://orcid.org/0000-0002-1704-9551)
- Songhua Cai (ORCID: https://orcid.org/0000-0003-3839-2030)
- Jiahao Qu
- Yiran Meng (ORCID: https://orcid.org/0000-0002-9333-2383)
- Liuqing Zheng (ORCID: https://orcid.org/0009-0003-6324-3595)
- Li Wang (ORCID: https://orcid.org/0000-0001-8527-6345)
- Wenyi Liu (ORCID: https://orcid.org/0000-0001-5920-9050)
- Xiaotong Guo (ORCID: https://orcid.org/0000-0002-4039-613X)
- Youjun Deng (ORCID: https://orcid.org/0000-0002-2904-6438)
- Chenglin Yang (ORCID: https://orcid.org/0000-0002-4247-9537)
- Jingting Wu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Southern University of Science and Technology (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1002/ctm2.70091
- Citations
- 5
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86