The protumorigenic enzyme GPAT2 inhibits arachidonic acid-triggered apoptosis in breast cancer
We concluded that GPAT2 expression is necessary to prevent AA-induced apoptotic cell death in MDA-MB-231 cells and that the overexpression of other AA-metabolizing genes is not sufficient to compensate for the lack of GPAT2 and prevent apoptosis.
Authors
- Mauro A. Montanaro
- María R. González-Baró (ORCID: https://orcid.org/0000-0002-6778-284X)
- Elizabeth R. Cattáneo (ORCID: https://orcid.org/0000-0001-8898-7513)
- Fiorella J. Ferremi
- Veronica V. Moscoso
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Biochemistry Research Institute of La Plata (AR)
- Universidad Nacional de La Plata (AR)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s12944-024-02344-1
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Universidad Nacional de La Plata