The intratumoral landscape of T cell receptor repertoire in esophageal squamous cell carcinoma
Our study primarily describes the landscape of TCR repertoires in ESCC through three aspects: differences in tumor tissues, immune response to immunotherapy, and survival prognosis of patients. These results emphasize the importance of TCR repertoire characteristics as unique and relevant biomarkers for ESCC immunotherapy.
Authors
- Dan He (ORCID: https://orcid.org/0009-0005-5244-6834)
- Meng Liu (ORCID: https://orcid.org/0000-0002-4679-5457)
- Meng Yang (ORCID: https://orcid.org/0000-0003-0629-8648)
- Lin Feng (ORCID: https://orcid.org/0000-0003-0951-713X)
- Yunquan Guo
- Yu Ma (ORCID: https://orcid.org/0000-0002-8800-5038)
- Yu Sun (ORCID: https://orcid.org/0000-0002-5364-2387)
Institutions
- Xinjiang Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tumor Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s12967-024-05825-0
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Xinjiang