Hydrophilic Metal–Organic Frameworks Regulated by Biomineralized Protein for Enhanced Stability and Drug Delivery

For bridging the gap between biological and synthetic materials, the fusion of Metal-Organic Frameworks (MOFs) with biological entities has emerged as a revolutionary strategy in functional materials. In this context, our study introduces a novel structure wherein Bovine Serum Albumin (BSA), a robust and versatile protein, encapsulates zeolitic imidazolate framework-8 (ZIF-8), forming a protein-caged MOF. Highlighting the advantages of this innovative design, the protein-encapsulation enhances the stability and dispersity of ZIF-8, and aids in the synthesis of smaller-sized nanoparticles, crucial for size-impact performance applications. Additionally, the BSA-caged ZIF-8 structure showcases potential in drug delivery applications, especially in the controlled delivery of chemotherapeutic drugs. The study thus elucidates the multifaceted applicability of this novel structure, marking a significant stride in the convergence of biological and synthetic materials.

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Publication Details

Journal
Nano Letters
Published
2024-11-27
DOI
https://doi.org/10.1021/acs.nanolett.4c04147
Citations
13
Primary Topic
Nanoparticle-Based Drug Delivery
Type
article
Field-Weighted Citation Impact
2.25

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article

Hydrophilic Metal–Organic Frameworks Regulated by Biomineralized Protein for Enhanced Stability and Drug Delivery

Sajid Ur Rehman, Haining Xia, Kun Ma, Hossein Kazemian et al.
13 citations
Nano Letters
Nanoparticle-Based Drug Delivery
2.25
article

Hydrophilic Metal–Organic Frameworks Regulated by Biomineralized Protein for Enhanced Stability and Drug Delivery

Sajid Ur Rehman, Haining Xia, Kun Ma, Hossein Kazemian, Shuai Kong, Jian Shen, Ruiguo Chen, Rida Ahmed, Shuai Xu, Junfeng Wang, Jing Zhang, Zehua Li, Yan-Yi Jiang, Zeyong Guo, Abbas Rehman
article en
13 citations

Abstract

For bridging the gap between biological and synthetic materials, the fusion of Metal-Organic Frameworks (MOFs) with biological entities has emerged as a revolutionary strategy in functional materials. In this context, our study introduces a novel structure wherein Bovine Serum Albumin (BSA), a robust and versatile protein, encapsulates zeolitic imidazolate framework-8 (ZIF-8), forming a protein-caged MOF. Highlighting the advantages of this innovative design, the protein-encapsulation enhances the stability and dispersity of ZIF-8, and aids in the synthesis of smaller-sized nanoparticles, crucial for size-impact performance applications. Additionally, the BSA-caged ZIF-8 structure showcases potential in drug delivery applications, especially in the controlled delivery of chemotherapeutic drugs. The study thus elucidates the multifaceted applicability of this novel structure, marking a significant stride in the convergence of biological and synthetic materials.

Nano LettersVol. 24(49)
University of Science and Technology of China (CN), Anhui University (CN), University of Northern British Columbia (CA), Chinese Academy of Sciences (CN), Hefei Institutes of Physical Science (CN), High Magnetic Field Laboratory (CN)
National Natural Science Foundation of China, Alliance of International Science Organizations, High-end Foreign Experts Recruitment Plan of China
Openalex Percentile: Top 12%
Nanoparticle-Based Drug Delivery
2.25
DOISourceOpenAlex
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