Case-Control Study of Cervicovaginal β/γ–Human Papillomavirus Infection in Women With Human Immunodeficiency Virus and Its Relation to Incident Cervical Precancer
We studied cervicovaginal β/γ-human papillomavirus (HPV) and their relationship to cervical precancer in women with human immunodeficiency virus; having previously reported strong positive associations of β/γ-HPV with incident head and neck cancer in the general population. Case patients (n = 124) had cervical intraepithelial neoplasia (CIN) 3 or 2. Controls (n = 247) were individually matched 2:1 to case patients. Unexpectedly, multivariate analyses found strong inverse associations between β/γ-HPV and CIN-2/3 (odds ratio, 0.19 [95% confidence interval, .04-.86]; P = .03; Ptrend < .01]). This is, to our knowledge, the first study of β/γ-HPV and cervical precancer. If confirmed, a strong inverse (protective) association would be of potential clinical and biologic relevance.
Authors
- Igho Ofotokun
- Jessica Atrio (ORCID: https://orcid.org/0000-0002-3505-643X)
- Howard Minkoff (ORCID: https://orcid.org/0000-0002-7800-7195)
- Lisa Rahangdale (ORCID: https://orcid.org/0000-0002-4444-7969)
- Gypsyamber DʼSouza (ORCID: https://orcid.org/0000-0002-0575-7948)
- Robert David Burk (ORCID: https://orcid.org/0000-0002-8376-8458)
- Lisa Flowers (ORCID: https://orcid.org/0000-0003-0484-2742)
- Nancy A. Hessol (ORCID: https://orcid.org/0000-0003-3374-8384)
- Adaora A. Adimora (ORCID: https://orcid.org/0000-0001-5035-1552)
- Mykhaylo Usyk (ORCID: https://orcid.org/0000-0002-0374-3753)
- N. Bachman
- Rodney Wright (ORCID: https://orcid.org/0000-0001-7922-3503)
- L. Stewart Massad (ORCID: https://orcid.org/0000-0001-8486-9464)
- Marla J. Keller (ORCID: https://orcid.org/0000-0003-0417-4000)
- Catalina Ramirez (ORCID: https://orcid.org/0000-0002-0872-0307)
- Kathryn Anastos (ORCID: https://orcid.org/0000-0002-0769-6405)
- Sadeep Shrestha (ORCID: https://orcid.org/0000-0002-7002-357X)
- Joel M. Palefsky (ORCID: https://orcid.org/0000-0002-5097-3818)
- Lorraine Sanchez-Keeland (ORCID: https://orcid.org/0000-0003-1669-1347)
- Margaret A. Fischl (ORCID: https://orcid.org/0000-0001-9241-5390)
- Howard D. Strickler (ORCID: https://orcid.org/0000-0002-7692-6147)
- Xiaonan Xue (ORCID: https://orcid.org/0000-0003-2872-8119)
- Xianhong Xie (ORCID: https://orcid.org/0000-0002-2032-1587)
- Isam-Eldin Eltoum
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Southern California (US)
- Albert Einstein College of Medicine (US)
- Maimonides Medical Center (US)
- Montefiore Medical Center (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Emory University (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1093/infdis/jiae588
- Citations
- 3
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- University of California, San Francisco
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Child Health and Human Development
- Office of Research on Women's Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development