Forging the tricyclic core framework of euphordraculoate B <i>via</i> a Barbier-type allyl addition
A novel strategy for the synthesis of an advanced intermediate <i>en route</i> to the tigliane derivative euphordraculoate B was described, which led to the successful construction of the 5/5/6 tricyclic core framework as well as the multiple consecutive stereocenters on the skeleton. Key steps of the strategy include a chlorination reaction, an aldol reaction, and a Barbier-type allyl addition.
Authors
- Pingping Tang (ORCID: https://orcid.org/0000-0002-8296-5695)
- Zhaobin Sun (ORCID: https://orcid.org/0000-0003-0832-2891)
- Longhui Meng (ORCID: https://orcid.org/0000-0002-3914-7419)
- Jingjing Liu (ORCID: https://orcid.org/0000-0002-5331-7015)
- Yumin Hou
- Qianwen Huang (ORCID: https://orcid.org/0000-0002-3553-2934)
Institutions
- Nankai University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1039/d4ob01743a
- Primary Topic
- Chemical synthesis and alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00