The development of the technology of a thick extract for the treatment of cheilitis

Aim. To substantiate the parameters of the technological process for obtaining an aqueous thick extract based on the medicinal plant raw material for the treatment of cheilitis. Materials and methods. The study objects were experimental samples of a phytocomplex (large burdock root: oak bark: pot marigold flower buds 5: 1: 1.5) and an aqueous thick extract obtained on its basis. During the development of the technology for obtaining a thick extract and its standardization, organoleptic, physicochemical and pharmacotechnological research methods were used in accordance with the methods and recommendations given in the SPhU 2.0. The results of the research were statistically processed in accordance with the requirements of monograph 5.3 of the SPhU 2.3. Results. The pharmacotechnological properties of the phytocomplex for the prevention and treatment of cheilitis – large burdock root: oak bark: pot marigold flower buds (5: 1: 1.5, respectively) were experimentally studied. The optimal conditions for extraction of the complex with purified water were determined; they were: temperature – 95-100 ºС; three-stage remaceration method; the total ratio of the raw material: finished extract (1:10). The technological parameters were worked out; the technological flowsheet of the process for obtaining an intermediate product – an aqueous thick extract under the conditional name “Phytol” was developed. Conclusions. Based on the studies conducted, the technological parameters of the extraction process for the phytocomplex proposed have been determined; the technology for obtaining an aqueous thick extract has been substantiated step-by-step, and its technological flowsheet has been drawn up.