Postmortem analyses of myocardial microRNA expression in sepsis
Several regulatory miRNAs were up-or down-regulated in the myocardial tissue of patients deceased with sepsis compared to non-septic subjects. The predicted target genes of miRNAs and miRNA-mRNA interaction analysis are associated with biological functions related to cardiovascular functions, cell viability, cell adhesion, and regulation of inflammatory and immune response.
Authors
- Pasi Lehto (ORCID: https://orcid.org/0000-0002-8088-6643)
- Tero Ala‐Kokko
- Hannu Syrjälä (ORCID: https://orcid.org/0000-0002-2872-2748)
- Hanna Säkkinen
- Jaana Karhu
- Katja Porvari (ORCID: https://orcid.org/0000-0002-5692-243X)
- Sini Skarp (ORCID: https://orcid.org/0000-0003-2336-4221)
- Risto Kerkelä (ORCID: https://orcid.org/0000-0001-7194-9326)
- Taru Saukko
- Lasse Pakanen (ORCID: https://orcid.org/0000-0002-3494-7652)
- Samu Saarimäki (ORCID: https://orcid.org/0000-0002-2054-3657)
- Sonja Bläuer
Institutions
- Oulu University Hospital (FI)
- Finnish Institute for Health and Welfare (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Scientific Reports
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1038/s41598-024-81114-6
- Citations
- 6
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.71