Lycorine ameliorates liver steatosis, oxidative stress, ferroptosis and intestinal homeostasis imbalance in MASLD mice
EGFR was the target of lycorine intervention in MASLD. Lycorine ameliorated hepatic steatosis, oxidative stress and ferroptosis by affecting the EGFR/PI3K/AKT signaling pathway in MASLD mice. Furthermore, lycorine promoted WAT browning and ameliorated intestinal homeostatic imbalance. The above effects may also have dose-dependent effects.
Authors
- Ya Gao (ORCID: https://orcid.org/0000-0002-4391-430X)
- Jiali Cao (ORCID: https://orcid.org/0009-0000-2806-0265)
- Zhifan Xiong (ORCID: https://orcid.org/0000-0001-7190-8073)
- Mengpei Zhu (ORCID: https://orcid.org/0000-0001-8588-413X)
- Qiangqiang Zhong (ORCID: https://orcid.org/0000-0002-5855-0270)
- Ze Jin (ORCID: https://orcid.org/0009-0003-5014-1194)
- Qian Li (ORCID: https://orcid.org/0000-0001-8827-939X)
- Ziwen Wang (ORCID: https://orcid.org/0000-0002-3724-1620)
- Qing Lan (ORCID: https://orcid.org/0000-0002-0888-8839)
- Yumei Huang (ORCID: https://orcid.org/0000-0003-1838-4076)
Institutions
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s10020-024-01003-6
- Citations
- 9
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 4.20