Lower estimated glomerular filtration rate relates to cognitive impairment and brain alterations
Lower eGFR is associated with reduced cognitive abilities.Structural brain changes are mediated by eGFR levels.Specific gene expression patterns correlate with lower eGFR and brain changes.Mitochondrial and inflammation-related genes were enriched in these patterns.
Authors
- Christina Tremblay (ORCID: https://orcid.org/0000-0002-7747-8147)
- Dominique S. Genest
- Shady Rahayel (ORCID: https://orcid.org/0000-0001-5786-3278)
- Rémi Goupil (ORCID: https://orcid.org/0000-0002-0098-3735)
- Florence Lamarche
- Mohsen Agharazii (ORCID: https://orcid.org/0000-0002-7628-5757)
- Violette Ayral
- François Madore
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Montreal General Hospital (CA)
- Hôpital du Sacré-Cœur de Montréal (CA)
- Université Laval (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70044
- Citations
- 4
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Fondation Brain Canada
- Alzheimer Society
- Parkinson Canada