Viral Hepatitis in Western Patients with Advanced Intrahepatic Cholangiocarcinoma: Retrospective Assessment of Prevalence, Prognostic and Predictive Significance
Despite a biologically established causative role of viral hepatitis (VH), i.e. HBV and HCV infections, on intrahepatic cholangiocarcinoma (ICC), only few large Western cohorts exploring the association between VH and ICC development are available. The prognostic significance of VH in ICC is debated, and no data are available regarding a predictive role for standard first-line CT (CT1), consisting of gemcitabine +/- platinoids. VH-positivity definition is often clinically incomplete and inconsistent among studies. Five different VH conditions, based on laboratory and anamnestic data, were investigated in a multicentric retrospective cohort of advanced ICC cases. Depending on the specific VH condition considered, 139-194 of 472 ICC cases could be categorized according to the presence of the mentioned VH conditions. VH prevalence ranged from 9.3 to 25.3%. No VH condition showed an impact on survival, although a non-significant worse outcome was observed for some HBV-related conditions. HCV-related conditions were associated to lower pre-CT1 biomarkers of inflammation, markedly higher disease control, and numerically longer time-to-progression with CT1. No benefit on time-to-progression was demonstrated for the addition of platinoids to gemcitabine in VH-positive patients (HR 0.77, CI<sub>95%</sub> 0.41-1.45), at least in HBV-related cases. These findings are clinically relevant and deserve further investigation.
Authors
- Luca Faloppi (ORCID: https://orcid.org/0000-0003-3689-3085)
- Massimo Di Maïo (ORCID: https://orcid.org/0000-0001-8906-3785)
- Francesca Salani (ORCID: https://orcid.org/0000-0001-7749-8634)
- Margherita Rimini (ORCID: https://orcid.org/0000-0002-4047-2585)
- Marzia Deserti (ORCID: https://orcid.org/0000-0001-7608-638X)
- Francesco Leone (ORCID: https://orcid.org/0000-0001-5422-9706)
- Mario Scartozzi (ORCID: https://orcid.org/0000-0001-5977-5546)
- Elisa Sperti
- Andrea Palloni (ORCID: https://orcid.org/0000-0003-1260-2765)
- Roberto Filippi (ORCID: https://orcid.org/0000-0001-9698-7687)
- Maria Antonietta Satolli (ORCID: https://orcid.org/0000-0002-1101-5721)
- Simona Tavolari (ORCID: https://orcid.org/0000-0002-2410-9698)
- Rosella Spadi (ORCID: https://orcid.org/0000-0003-2589-2415)
- Giovanni Brandi (ORCID: https://orcid.org/0000-0003-0013-2858)
- Stefania Eufemia Lutrino
- Nicola Silvestris (ORCID: https://orcid.org/0000-0001-7814-7318)
- Oronzo Brunetti (ORCID: https://orcid.org/0000-0002-7014-6828)
- Giuseppe Aprile (ORCID: https://orcid.org/0000-0003-2007-4077)
- Daniele Santini (ORCID: https://orcid.org/0000-0002-9118-3337)
- Andrea Casadei‐Gardini (ORCID: https://orcid.org/0000-0001-6289-7202)
- Depetris Ilaria
Institutions
- University of Pisa (IT)
- University of Messina (IT)
- Vita-Salute San Raffaele University (IT)
- Scuola Superiore Sant'Anna (IT)
- University of Cagliari (IT)
- Policlinico Umberto I (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale degli Infermi (IT)
- Ospedale A. Perrino (IT)
- Azienda USL di Bologna (IT)
- A. O. Ordine Mauriziano di Torino (IT)
- Istituto Tumori Bari (IT)
- Ospedale San Bortolo (IT)
- Ospedale degli Infermi (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Turin (IT)
- University of Bari Aldo Moro (IT)
- Sapienza University of Rome (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Cancer Investigation
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1080/07357907.2024.2432013
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00