Even moderate liver fat accumulation below conventional fatty liver cutoffs is linked to multiple metabolomic alterations and gestational dysglycemia in Asian women of reproductive age
In Asian women of reproductive age, moderate liver fat accumulation below the conventional fatty liver cutoff was not metabolically benign and was linked to gestational dysglycemia. The newly derived cutoff can aid in screening individuals before adverse metabolic phenotypes have consolidated, which provides a longer window for preventive strategies.
Authors
- Peter D. Gluckman
- Yap Seng Chong (ORCID: https://orcid.org/0000-0002-7232-8473)
- S. Sendhil Velan (ORCID: https://orcid.org/0000-0002-4096-0722)
- Priti Mishra (ORCID: https://orcid.org/0000-0001-5431-1574)
- Jadegoud Yaligar (ORCID: https://orcid.org/0000-0002-6050-5241)
- Keith M. Godfrey (ORCID: https://orcid.org/0000-0002-4643-0618)
- Dennis Wang (ORCID: https://orcid.org/0000-0003-0068-1005)
- Kok Hian Tan (ORCID: https://orcid.org/0000-0003-1945-0266)
- Navin Michael (ORCID: https://orcid.org/0000-0002-6170-2108)
- Suresh Anand Sadananthan (ORCID: https://orcid.org/0000-0001-5938-1694)
- Marielle V. Fortier (ORCID: https://orcid.org/0000-0002-3294-1054)
- Jerry Kok Yen Chan
- Johan G. Eriksson
- Shiao-Yng Chan
Institutions
- Agency for Science, Technology and Research (SG)
- University of Helsinki (FI)
- University of Auckland (NZ)
- National University of Singapore (SG)
- Singapore Institute for Clinical Sciences (SG)
- KK Women's and Children's Hospital (SG)
- NIHR Southampton Biomedical Research Centre (GB)
- MRC Lifecourse Epidemiology Unit (GB)
- Bioinformatics Institute (SG)
- Folkhälsans Forskningscentrum (FI)
- University of Southampton (GB)
- Imperial College London (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s12916-024-03779-0
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Precursory Research for Embryonic Science and Technology