Enhanced Parkin-mediated mitophagy mitigates adverse left ventricular remodelling after myocardial infarction: role of PR-364
This study demonstrates the therapeutic potential of targeting Parkin-mediated mitophagy using PR-364 to protect surviving cardiac tissue post-MI from progression to HF.
Authors
- Lizhuo Ai (ORCID: https://orcid.org/0000-0001-5449-9888)
- Jennifer E. Van Eyk (ORCID: https://orcid.org/0000-0001-9050-148X)
- Marianne Aniag (ORCID: https://orcid.org/0000-0002-4751-5824)
- Christopher Rainville (ORCID: https://orcid.org/0000-0003-0027-8670)
- Reetu Thakur (ORCID: https://orcid.org/0000-0002-3946-2419)
- Roberta A. Gottlieb (ORCID: https://orcid.org/0000-0002-1432-006X)
- Jon Sin (ORCID: https://orcid.org/0000-0002-2567-3223)
- Deepika Rai (ORCID: https://orcid.org/0000-0001-6738-3702)
- Aleksandr Stotland (ORCID: https://orcid.org/0000-0003-4794-1097)
- Robert M. Mentzer (ORCID: https://orcid.org/0000-0003-2258-7570)
- Honit Piplani (ORCID: https://orcid.org/0000-0002-0177-2980)
- Juliana de Freitas Germano (ORCID: https://orcid.org/0000-0001-5924-2483)
- Savannah Sawaged (ORCID: https://orcid.org/0000-0002-4259-9037)
- Suresh Kumar (ORCID: https://orcid.org/0000-0002-1940-772X)
- David E. Sterner (ORCID: https://orcid.org/0000-0003-1942-165X)
- Chengqun Huang
- Tauseef R. Butt
- Yang Song (ORCID: https://orcid.org/0009-0002-4380-2065)
Institutions
- Cedars-Sinai Medical Center (US)
- Progenra (United States) (US)
- Cedars-Sinai Smidt Heart Institute (US)
Publication Details
- Journal
- European Heart Journal
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1093/eurheartj/ehae782
- Citations
- 28
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 10.83
Funders
- Michael J. Fox Foundation for Parkinson's Research
- California Institute for Regenerative Medicine
- Cedars-Sinai Medical Center
- Erika Glazer Family Foundation
- Comissão Interministerial para os Recursos do Mar
- Norges Idrettshøgskole
- National Institutes of Health