Gut microbiota dysbiosis induced by alcohol exposure in pubertal and adult mice
This study elucidates the significant impact of alcohol exposure on the gut microbiota and metabolic pathways in mice, highlighting the differential responses between adolescent and adult stages. Alcohol exposure was found to damage the intestinal barrier, alter the microbial composition by decreasing beneficial bacteria like <i>Lactobacillus</i>, and increase harmful bacteria such as <i>Alistipes</i>. The study also discovered unique microbial changes and resilience in pubertal mice. Species-level metagenomic analysis revealed specific microbial taxa and metabolic functions affected by alcohol. Metagenome-assembled genomes (MAGs) found many species that could not be annotated by conventional methods including many members of <i>Lachnospiraceae</i>, greatly expanding our understanding of the gut microbiota composition. These findings underscore the need for further research on alcohol's effects on various organs and the implications of microbial metabolites on disease progression.
Authors
- Xiaoqian Lin (ORCID: https://orcid.org/0000-0002-1158-6962)
- Jianmei Liu (ORCID: https://orcid.org/0000-0002-8179-031X)
- Tongyuan Hu (ORCID: https://orcid.org/0000-0003-4172-3136)
- Yuanqiang Zou (ORCID: https://orcid.org/0000-0003-2380-264X)
- Yue Feng (ORCID: https://orcid.org/0000-0001-6740-979X)
- Hewei Liang (ORCID: https://orcid.org/0000-0003-4639-6314)
- Haoyu Wang (ORCID: https://orcid.org/0000-0001-8236-3187)
- Jincen Liu
- Y. Bai (ORCID: https://orcid.org/0000-0002-2957-7319)
- Jinlong Yang (ORCID: https://orcid.org/0000-0002-5651-5340)
- Jianghua Lai (ORCID: https://orcid.org/0000-0003-0851-4412)
- Shuguang Wei (ORCID: https://orcid.org/0000-0003-2954-344X)
- Zhinan Wu
- Peng Yan
Institutions
- BGI Group (China) (CN)
- Qingdao University (CN)
- Botswana Geoscience Institute (BW)
- Human Computer Interaction (Switzerland) (CH)
- University of Chinese Academy of Sciences (CN)
- BGI Research (CN)
- Xi'an Jiaotong University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- mSystems
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1128/msystems.01366-24
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Government of Jiangxi Province
- Yakult Bio-Science Foundation
- Key Research and Development Projects of Shaanxi Province