Human T cells engineered with an HLA-A2-restricted murine T-cell receptor targeting glypican 3 effectively control human hepatocellular carcinoma in mice
Transgenic TCRs join forces with CARs, expanding the arsenal of GPC3-targeting receptors for HCC T-cell therapy.
Authors
- Enric Vercher (ORCID: https://orcid.org/0000-0002-1594-9898)
- Ibón Tamayo (ORCID: https://orcid.org/0000-0002-8183-7106)
- Sandra Hervás‐Stubbs (ORCID: https://orcid.org/0000-0003-3391-1516)
- Maritza Roxana García-García (ORCID: https://orcid.org/0000-0002-2996-8264)
- Ángela Covo-Vergara
- Marta Ruiz (ORCID: https://orcid.org/0000-0002-8757-0932)
- Susana Inogés (ORCID: https://orcid.org/0000-0002-9370-8416)
- Edurne Elizalde (ORCID: https://orcid.org/0000-0002-6510-1844)
- Mercedes Iñarrairaegui (ORCID: https://orcid.org/0000-0001-9180-4693)
- Enrique Conde (ORCID: https://orcid.org/0000-0002-3587-1506)
- David Repáraz (ORCID: https://orcid.org/0000-0003-2706-6870)
- Javier Glez‐Vaz (ORCID: https://orcid.org/0000-0001-8936-190X)
- Pablo Sarobe (ORCID: https://orcid.org/0000-0003-0503-7905)
- Uxua Mancheño (ORCID: https://orcid.org/0000-0003-1533-0371)
- Juan José Lasarte (ORCID: https://orcid.org/0000-0003-1641-3881)
- Bruno Sangro (ORCID: https://orcid.org/0000-0002-4177-6417)
- Mercedes Hernández-Rueda
- Ascensión López-Díaz De Cerio
- Marta Ferrer-Roig
- Javier Marañón-Lopez
Institutions
- Universidad Autónoma de Guadalajara (MX)
- Universidad de Guadalajara (MX)
- Navarre Institute of Health Research (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Clinica Universidad de Navarra (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Hepatology
- Published
- 2024-11-26
- DOI
- https://doi.org/10.1097/hep.0000000000001175
- Citations
- 5
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.41