Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling
We explored the potential molecular basis for the spontaneous resolution of MSU induced acute inflammation using a cell-based model in that huge NET-MSU aggregates frustrate the transformation of newly entering PMNs to the N2 phenotype, enhancing the production of the anti-inflammatory cytokine IL-1RA.
Authors
- Chieh‐Yu Shen (ORCID: https://orcid.org/0000-0002-3218-0689)
- Song‐Chou Hsieh (ORCID: https://orcid.org/0000-0001-8058-7566)
- Ko‐Jen Li (ORCID: https://orcid.org/0000-0002-4544-4620)
- Chia‐Li Yu (ORCID: https://orcid.org/0000-0003-4988-0400)
- Yu‐Min Kuo (ORCID: https://orcid.org/0000-0002-5797-6093)
- Yu-Hsuan Chen (ORCID: https://orcid.org/0000-0002-8131-3134)
- Cheng‐Hsun Lu (ORCID: https://orcid.org/0000-0002-4794-9438)
- Chih-Hao Wu (ORCID: https://orcid.org/0009-0004-0405-3238)
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s12950-024-00423-9
- Citations
- 11
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.65
Funders
- National Science Council
- National Taiwan University Hospital
- National Taiwan University