Maintenance with 5-FU/LV-aflibercept after induction with FOLFIRI-aflibercept versus FOLFIRI-aflibercept until progression as second-line treatment in older adults with metastatic colorectal cancer: the AFEMA phase II randomized trial
In older adults, induction with six cycles of FOLFIRI-A plus maintenance with 5-FU/LV-A was non-inferior to FOLFIRI-A until progression. Severe asthenia, SAEs, and treatment-related SAEs were reduced with 5-FU/LV-A maintenance.
Authors
- Ana Fernández Montés (ORCID: https://orcid.org/0000-0003-4630-5830)
- Cristina Grávalos (ORCID: https://orcid.org/0000-0001-9239-6505)
- C. López-López (ORCID: https://orcid.org/0000-0002-3965-7419)
- Tomás Fernández‐Rodríguez (ORCID: https://orcid.org/0000-0002-4271-2415)
- Marta Guix (ORCID: https://orcid.org/0000-0002-2143-0697)
- Alfonso Yubero (ORCID: https://orcid.org/0000-0003-4995-0325)
- Élena Elez (ORCID: https://orcid.org/0000-0002-4653-6324)
- I Macías
- Guillermo Quintero (ORCID: https://orcid.org/0000-0002-3671-6911)
- David Páez (ORCID: https://orcid.org/0000-0002-5596-6588)
- J. Sastre
- Encarnación González‐Flores (ORCID: https://orcid.org/0000-0002-2077-5060)
- Enrique Aranda (ORCID: https://orcid.org/0000-0002-5471-2842)
- Beatriz Paredes
- Antonieta Salud (ORCID: https://orcid.org/0000-0002-7399-7484)
- Pilar García‐Alfonso (ORCID: https://orcid.org/0000-0002-4373-9978)
- J.J. Reina
- James F. Mowbray
- María Auxiliadora Gómez‐España
- Javier Soto‐Alsar
Institutions
- Hebron University (PS)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Hospital Universitari Arnau de Vilanova (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Clínico San Carlos (ES)
- Hospital Son Llatzer (ES)
- Hospital Universitario Virgen Macarena (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Hospital Universitario 12 De Octubre (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Hospital Universitario Reina Sofía (ES)
- Hospital de Sabadell (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Del Mar (ES)
- Hospital Clínico Universitario Lozano Blesa (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- Hospital Universitario Lucus Augusti (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Instituto de Investigación Biomédica de A Coruña (ES)
- Complejo Hospitalario de Ourense (ES)
- University of Córdoba (ES)
Publication Details
- Journal
- ESMO Open
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1016/j.esmoop.2024.103986
- Citations
- 1
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- Sanofi