Human Pulmonary Neuroendocrine Cells Respond to House Dust Mite Extract With <scp>PAR</scp> ‐1 Dependent Release of <scp>CGRP</scp>
We have characterized a novel model of PNEC-enriched human airway epithelium and utilized this model to demonstrate a previously unrecognized role for human PNEC in mediating a direct neuroendocrine response to aeroallergen exposure.
Authors
- Paul Forsythe (ORCID: https://orcid.org/0000-0002-1460-0491)
- Ritu Mann‐Nüttel (ORCID: https://orcid.org/0000-0001-5660-8304)
- Lakshmi Puttagunta (ORCID: https://orcid.org/0000-0002-0840-9041)
- Shivani Mandal (ORCID: https://orcid.org/0000-0003-3576-0299)
- Marie Armbruster (ORCID: https://orcid.org/0009-0008-0941-7271)
Institutions
- University of Alberta (CA)
Publication Details
- Journal
- Allergy
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1111/all.16416
- Citations
- 7
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- AstraZeneca
- Canadian Allergy, Asthma and Immunology Foundation
- AstraZeneca Canada
- Canadian Institutes of Health Research