In Silico Design of Peptide Inhibitors Targeting HER2 for Lung Cancer Therapy
Pep-7 emerged as the most promising therapeutic peptide, displaying strong binding stability, favorable binding free energy, and molecular stability in HER2-overexpressing cancer models. These findings suggest pep-7 as a viable therapeutic candidate for HER2-positive cancers, offering a potential novel treatment strategy against HER2-driven malignancies.
Authors
- Heba Alkhatabi (ORCID: https://orcid.org/0000-0003-2097-2010)
- Hisham N. Alatyb
Institutions
- King Abdulaziz University (SA)
Publication Details
- Journal
- Cancers
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3390/cancers16233979
- Citations
- 3
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.08
Funders
- King Abdulaziz University