Taurine Supplementation Alleviates Blood Pressure via Gut–Brain Communication in Spontaneously Hypertensive Rats
Taurine supplementation restored the microbiota balance, strengthened the mucosal barrier, reduced intestinal inflammation, and stimulated tryptophan metabolism. The metabolites derived from the gut microbiota likely crossed the brain barrier and reached the paraventricular nucleus, thereby reducing the inflammatory responses and oxidative stress in the PVN via gut-brain communication, leading to decreased sympathetic nerve activity and blood pressure in the studied hypertensive rats.
Authors
- Guiqing Zou
- Qing Su (ORCID: https://orcid.org/0000-0003-1462-4503)
- Xiangbin Pan (ORCID: https://orcid.org/0000-0002-2252-3393)
- Ling-Xiao Xiong
- Juan Bai (ORCID: https://orcid.org/0000-0001-6259-2337)
- Huan Zhang (ORCID: https://orcid.org/0000-0002-4273-1907)
- Lu Li (ORCID: https://orcid.org/0000-0003-4175-5592)
- Lili Huang (ORCID: https://orcid.org/0000-0002-9757-315X)
- Nana Zhang (ORCID: https://orcid.org/0009-0008-0487-4019)
- Hong‐Bao Li (ORCID: https://orcid.org/0000-0002-1600-9590)
- Xiaomin Wang
- Xiaoying Qu
- Menglu Xu (ORCID: https://orcid.org/0009-0004-2074-8646)
- Yang Shen
Institutions
- Northwest University (CN)
- Xi'an Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Hunan Children's Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3390/biomedicines12122711
- Citations
- 5
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Fundamental Research Funds for the Central Universities