Direct Interaction Between CD34+ Hematopoietic Stem Cells and Mesenchymal Stem Cells Reciprocally Preserves Stemness
In conclusion, under physiological conditions, connexin 43 and N-Cadherin interaction preserves stemness of both CD34<sup>+</sup> HSCs and MSCs, a process that is compromised in acute myeloid leukemia, pointing to the possible role of gap junctions in modulating stemness.
Authors
- Inés Zugasti (ORCID: https://orcid.org/0000-0002-7666-5055)
- Pablo Menéndez (ORCID: https://orcid.org/0000-0001-9372-1007)
- Rémi Safi (ORCID: https://orcid.org/0000-0002-1697-872X)
- Kazem Zibara (ORCID: https://orcid.org/0000-0002-9887-072X)
- Hiba El Hajj (ORCID: https://orcid.org/0000-0002-1069-0477)
- Jamal El Saghir (ORCID: https://orcid.org/0000-0002-3779-4583)
- Farah Kouzi (ORCID: https://orcid.org/0000-0003-0506-0689)
- Tala Mohsen‐Kanson
- Vera Dermesrobian
- Marwan El‐Sabban
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Lebanese University (LB)
- University of Michigan (US)
- Instituto de Salud Carlos III (ES)
- Josep Carreras Leukaemia Research Institute (ES)
- Hospital Clínic de Barcelona (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- American University of Beirut (LB)
- KU Leuven (BE)
Publication Details
- Journal
- Cancers
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3390/cancers16233972
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.44