Tumor Expression of CD83 Reduces Glioma Progression and Is Associated with Reduced Immunosuppression
Immunosuppression in malignant glioma remains a barrier to therapeutic development. CD83 overexpression in human and mouse glioma increases survival. CD83+ tumor cells promote signatures related to cytotoxic T cells, enhanced activation of CD8+ T cells, and increased proinflammatory cytokines. These findings suggest that tumor-expressed CD83 could mediate tumor-immune communications.
Authors
- Carrie Mohila (ORCID: https://orcid.org/0000-0002-0261-0406)
- Ganesh Rao (ORCID: https://orcid.org/0000-0003-3609-3491)
- Peihao He (ORCID: https://orcid.org/0000-0003-0356-3995)
- Anna Rosenbaum (ORCID: https://orcid.org/0000-0002-0678-8535)
- Zhung-Fu Lee (ORCID: https://orcid.org/0000-0002-6500-3179)
- Malcolm F. McDonald (ORCID: https://orcid.org/0000-0002-2627-9754)
- Arif Harmanci (ORCID: https://orcid.org/0000-0002-9696-1118)
- Benjamin Deneen (ORCID: https://orcid.org/0000-0002-6335-1081)
- Akdes Serin Harmancı (ORCID: https://orcid.org/0000-0001-6374-9041)
- Brittney Lozzi (ORCID: https://orcid.org/0000-0001-6876-8479)
- Rachel Naomi Curry (ORCID: https://orcid.org/0000-0002-2793-2022)
- Alexis Cervantes
- Isabella O’Reilly
Institutions
- Baylor College of Medicine (US)
- Texas Children's Hospital (US)
- The University of Texas Health Science Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0281
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Cancer Prevention and Research Institute of Texas
- National Institutes of Health