Neuraminidase Antibody Response to Homologous and Drifted Influenza A Viruses After Immunization with Seasonal Influenza Vaccines

Drift A/H1N1pdm09 and A/H3N2 viruses demonstrated significantly lower reactivity to HI and NI antibodies against early influenza viruses. In response to seasonal IIVs, the level of seroprotection has increased, including against drift influenza A viruses, but protective antibody levels against A/H1N1pdm09 have risen to a greater extent. A reduced immune response to the N1 protein of the A/H1N1pdm09 drift virus was obtained in individuals under 60 years of age. Based on our findings, it is hypothesized that in the cases of a HA mismatch, vaccination against N1-containing influenza viruses may be necessary for individuals under 60, while broader population-level vaccination against N2-containing viruses may be required.

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Publication Details

Journal
Vaccines
Published
2024-11-27
DOI
https://doi.org/10.3390/vaccines12121334
Primary Topic
Influenza Virus Research Studies
Type
article
Field-Weighted Citation Impact
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article

Neuraminidase Antibody Response to Homologous and Drifted Influenza A Viruses After Immunization with Seasonal Influenza Vaccines

Ekaterina Bazhenova, Dmitry A. Lioznov, Ekaterina Romanovskaya-Romanko, Irina Kiseleva et al.
Vaccines
Influenza Virus Research Studies
article

Neuraminidase Antibody Response to Homologous and Drifted Influenza A Viruses After Immunization with Seasonal Influenza Vaccines

Ekaterina Bazhenova, Dmitry A. Lioznov, Ekaterina Romanovskaya-Romanko, Irina Kiseleva, Ekaterina Stepanova, Maria V. Sergeeva, V. Z. Krivitskaya, Yulia Desheva, Marina Stukova, Polina Kudar, Evelina Krylova, Andrey Rekstin, Kira Kudria, Maria Kurpiaeva
article en

Abstract

Drift A/H1N1pdm09 and A/H3N2 viruses demonstrated significantly lower reactivity to HI and NI antibodies against early influenza viruses. In response to seasonal IIVs, the level of seroprotection has increased, including against drift influenza A viruses, but protective antibody levels against A/H1N1pdm09 have risen to a greater extent. A reduced immune response to the N1 protein of the A/H1N1pdm09 drift virus was obtained in individuals under 60 years of age. Based on our findings, it is hypothesized that in the cases of a HA mismatch, vaccination against N1-containing influenza viruses may be necessary for individuals under 60, while broader population-level vaccination against N2-containing viruses may be required.

VaccinesVol. 12(12)
Ministry of Health of the Russian Federation (RU), Institute of Experimental Medicine (RU), Research Institute of Influenza (RU)
Good health and well-being
Openalex Percentile: Top 68%
Influenza Virus Research Studies
DOIOpen Access PDFOpenAlex
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Neuraminidase Antibody Response to Homologous and Drifted Influenza A Viruses After Immunization with Seasonal Influenza Vaccines — Ekaterina Bazhenova, Dmitry A. Lioznov, et al. · Vaccines (2024) | TGRS Research Map | TGRS