Investigating sex-related differences in brain structure and function in bipolar I disorder using multimodal MRI
Our findings revealed a noteworthy sex-by-diagnosis interaction, with male individuals with bipolar I disorder displaying larger gray matter volume and altered functional connectivity in the limbic system compared to female individuals with bipolar I disorder and healthy participants. These results hint at potential sex-related differences in the pathophysiology of the limbic system in bipolar I disorder, which may have significant implications for understanding the underlying mechanisms in bipolar I disorder. Our findings could contribute to developing more personalized treatment approaches for individuals with bipolar I disorder.
Authors
- Hsin-Jung Tsai (ORCID: https://orcid.org/0000-0002-1387-9240)
- Shih‐Jen Tsai (ORCID: https://orcid.org/0000-0002-9987-022X)
- Jun‐Ding Zhu (ORCID: https://orcid.org/0000-0003-0718-4087)
- Albert C. Yang (ORCID: https://orcid.org/0000-0003-2794-9649)
- Ming-Yang Lee
Institutions
- National Yang Ming Chiao Tung University (TW)
- Taipei Veterans General Hospital (TW)
- Chung Shan Medical University Hospital (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1186/s12888-024-06228-7
- Citations
- 4
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.54
Funders
- Ministry of Health and Welfare
- Shanghai Educational Development Foundation
- Ministry of Education, India
- Taipei Veterans General Hospital
- National Science and Technology Council
- Centers for Disease Control and Prevention