Pharmacokinetics of Oral Cannabinoid Δ8-Tetrahydrocannabivarin and Its Main Metabolites in Healthy Participants
For the first time, we report the pharmacokinetics of Δ8-THCV and its major metabolites after oral administration in humans. Δ8-THCV AUC<sub>last</sub> showed dose linearity but the observed possible conversion to the Δ9-THCV isomer should be further studied.
Authors
- Erica N. Peters (ORCID: https://orcid.org/0000-0002-5563-9819)
- Laura MacNair
- Marcel O. Bonn‐Miller (ORCID: https://orcid.org/0000-0001-5088-5386)
- Cristina Sempio (ORCID: https://orcid.org/0000-0002-8095-612X)
- Shanna L. Babalonis (ORCID: https://orcid.org/0000-0002-1450-2621)
- Uwe Christians (ORCID: https://orcid.org/0000-0001-7297-147X)
- Jost Klawitter (ORCID: https://orcid.org/0000-0002-6413-4820)
- Jelena Klawitter (ORCID: https://orcid.org/0000-0003-1893-6141)
- Mehdi Haghdoost
- Jorge Campos-Palomino
- Amy Harrison
Institutions
- University of Kentucky (US)
- Charlotte's Web (United States) (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3390/ph17121603
- Citations
- 1
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.45