The Stimulator of Interferon Genes Deficiency Attenuates Diabetic Myopathy Through Inhibiting NLRP3‐Mediated Pyroptosis
In conclusion, our results indicate that STING-induced activation of the NLRP3 inflammasome leads to pyroptosis, resulting in muscle atrophy and dysfunction. These findings not only elucidate the mechanism of STING-induced pyroptosis but also identify STING as a potential therapeutic target for diabetic myopathy.
Authors
- M.M. Wang
- Jingjuan Yang
- Xin Fang (ORCID: https://orcid.org/0000-0002-7274-8195)
- Yi Yang (ORCID: https://orcid.org/0000-0002-6285-0807)
- Yong‐Fei Wang (ORCID: https://orcid.org/0000-0003-3139-7701)
- Cui Gao
- Lingling Shi
- Songmin Ying (ORCID: https://orcid.org/0000-0001-7053-0793)
- Lin Ma (ORCID: https://orcid.org/0000-0001-6446-1824)
Institutions
- Chinese University of Hong Kong, Shenzhen (CN)
- Zhejiang University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1002/jcsm.13649
- Citations
- 10
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.34