Lentivirus-Mediated Missense Mutation in HtrA1 Leads to Activation of the TGF-β/Smads Pathway and Increased Apoptosis of Mouse Brain Microvascular Endothelial Cells via the Oxidative Stress Pathway
Lentivirus-mediated missense mutation in <i>HtrA1</i> leads to activation of the TGF-β/Smads pathway and to increased apoptosis of mouse brain microvascular endothelial cells via the oxidative stress pathway. Further <i>in vivo</i> studies are required to explore the connections between different signaling pathways in animals, and to identify potential molecular targets for clinical therapy.
Authors
- Jian-lin Liang
- Changxin Li (ORCID: https://orcid.org/0000-0001-8652-4283)
- Sui-yi Xu (ORCID: https://orcid.org/0000-0002-8908-011X)
- Shi-na Song
- Huijuan Li (ORCID: https://orcid.org/0000-0003-4789-2926)
- Qiuhe Ren (ORCID: https://orcid.org/0000-0003-1491-7867)
Institutions
- Central South University (CN)
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
- Taiyuan Iron and Steel Group (China) (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2024-10-31
- DOI
- https://doi.org/10.31083/j.jin2311201
- Citations
- 1
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.37