Next-Generation Sequencing for HLA Genotype Screening and Matching to HLA-Restricted Therapies
This case series evaluates whether human leukocyte antigen ( HLA ) genotype could be inferred from standard next-generation sequencing, comparing concordance with confirmatory whole-exome sequencing and assessing if this assisted in matching patients to clinical trials.
Authors
- Cynthia Chu
- Claire F. Friedman (ORCID: https://orcid.org/0000-0003-2621-8553)
- Kaelyn Kohlasch (ORCID: https://orcid.org/0000-0003-3170-7861)
- Michael V. Gormally (ORCID: https://orcid.org/0000-0002-0414-4234)
- Michael Eubank
- Adam J. Schoenfeld (ORCID: https://orcid.org/0000-0002-2644-1416)
- Anne Marie Noronha (ORCID: https://orcid.org/0000-0002-9066-8623)
- Chrisann Kyi (ORCID: https://orcid.org/0000-0003-3286-1860)
- Clare Wilhelm (ORCID: https://orcid.org/0000-0003-2437-5387)
- Mark T.A. Donoghue (ORCID: https://orcid.org/0000-0003-4538-6069)
- Nikeysha Clarke
- Mark G. Kris (ORCID: https://orcid.org/0000-0002-7317-5341)
- Alexander Noor Shoushtari (ORCID: https://orcid.org/0000-0002-8065-4412)
- Charles M. Rudin (ORCID: https://orcid.org/0000-0001-5204-3465)
- Ronak H. Shah (ORCID: https://orcid.org/0000-0001-9042-6213)
- Alexander Edward Dela Cruz Drilon (ORCID: https://orcid.org/0000-0001-6806-9061)
- David H. Aggen (ORCID: https://orcid.org/0000-0003-3963-5751)
- Monica F. Chen (ORCID: https://orcid.org/0000-0002-7485-2463)
- Christopher Austin Klebanoff (ORCID: https://orcid.org/0000-0001-9645-3896)
- Amanda G. Blouin (ORCID: https://orcid.org/0000-0003-2238-4837)
- Bryan Novak
- Chaitanya Bandlamudi (ORCID: https://orcid.org/0000-0003-1108-4919)
- Sandra P. D’Angelo (ORCID: https://orcid.org/0000-0002-3736-3783)
- Tatiana Kee-Velez
- Michael F. Berger
- Kristalla Panageas
- Maggie Reynolds
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Molecular Oncology (United States) (US)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1001/jamaoncol.2024.5364
- Citations
- 3
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52