HDL Cholesterol-Associated Shifts in the Expression of Preselected Genes Reveal both Pro-Atherogenic and Atheroprotective Effects of HDL in Coronary Artery Disease
The increased accumulation of cholesteryl ester in PBMC from patients with low HDL-C was suggested. This assumption contrasts with the suggested accumulation of free cholesterol in PBMC from patients with increased HDL-C, concomitant with suppression of cholesterol synthesis and traffic to the plasma membrane, and with an inflammatory state controlled by depressed CD36-mediated and upregulated apoE-mediated immunometabolic signaling. Gene signatures may be used for the diagnosis, prognosis, and treatment of CAD in dependence on HDL-C levels.
Authors
- Mikhail А. Popov (ORCID: https://orcid.org/0000-0002-0316-8410)
- Limborskaia Sa (ORCID: https://orcid.org/0000-0002-1697-6820)
- Elena V. Nosova
- А В Рожкова
- Veronika B. Baserova (ORCID: https://orcid.org/0000-0001-8845-6325)
- Alexander D. Dergunov (ORCID: https://orcid.org/0000-0002-0781-9890)
- Margarita A. Vinogradina (ORCID: https://orcid.org/0009-0002-1303-8270)
- Liudmila V. Dergunova
Institutions
- Kurchatov Institute (RU)
- National Research Center for Preventive Medicine (RU)
- Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky (RU)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-11-21
- DOI
- https://doi.org/10.31083/j.fbl2911396
- Citations
- 7
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.01