The PLCG2 Inhibits Tumor Progression and Mediates Angiogenesis by VEGF Signaling Pathway in Clear Cell Renal Cell Carcinoma
Our results show that PLCG2 functions as a potential biomarker and an independent prognostic indicator for ccRCC. PLCG2 may modulate angiogenesis by influencing the expression of VEGFA. Therefore, targeting PLCG2 could potentially lead to drug discovery and improved cancer treatment strategies.
Authors
- Qingyang Lv (ORCID: https://orcid.org/0009-0006-0671-0988)
- Daojia Miao (ORCID: https://orcid.org/0000-0002-7780-1282)
- Diaoyi Tan (ORCID: https://orcid.org/0009-0006-1896-9700)
- Chuanyi Zhao
- Xiaoping Zhang (ORCID: https://orcid.org/0000-0003-0218-3288)
- Zhiyong Xiong
- Jian Shi (ORCID: https://orcid.org/0000-0003-4115-8819)
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-11-20
- DOI
- https://doi.org/10.31083/j.fbl2911390
- Citations
- 4
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China