Severe Coronary Artery Calcifications in Chronic Kidney Disease Patients, Coupled with Inflammation and Bone Mineral Disease Derangement, Promote Major Adverse Cardiovascular Events through Vascular Remodeling
CAC constitutes a significant CV risk, further exacerbated by inflammation, hyperparathyroidism, and regulation of bone molecules implicated in calcification progression. This finding aligns with the original concept of multiple hits. Consequently, addressing the detrimental environment that fosters plaque vulnerability, reducing chronic low-grade inflammation, and normalizing mineral metabolism markers (such as vitamin D and PTH) and bone-regulating molecules may emerge as a viable therapeutic strategy.
Authors
- Jean‐Paul Cristol (ORCID: https://orcid.org/0000-0001-8563-7278)
- Hélène Leray‐Moragues
- Anne‐Marie Dupuy (ORCID: https://orcid.org/0000-0001-6538-3944)
- Marion Moréna (ORCID: https://orcid.org/0000-0001-9563-5217)
- Bernard Canaud (ORCID: https://orcid.org/0000-0001-6854-2816)
- Kada Klouche (ORCID: https://orcid.org/0000-0003-1633-7700)
- Isabelle Jaussent (ORCID: https://orcid.org/0000-0002-8205-7590)
- Anne‐Sophie Bargnoux
- Leïla Chénine
- H. Vernhet
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Institute for Neurosciences of Montpellier (FR)
Publication Details
- Journal
- Kidney & Blood Pressure Research
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1159/000542418
- Citations
- 3
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.02
Funders
- Ministère de la Santé