Remote Alkynylation of Aliphatic Amines
Advancements in transition metal catalyzed C-H activation/functionalization cascades have allowed the synthetic chemist's toolbox to be significantly expanded. Despite this, protocols for the remote alkynylation of linear aliphatic amines still remain limited. Herein, a palladium-catalyzed directing-group approach to alkynylation of aliphatic amines is disclosed. The synthetic utility was demonstrated with a gram-scale reaction and a functional group compatibility test.
Authors
- Peter D. Smith (ORCID: https://orcid.org/0000-0001-5312-9893)
- Rachel H. Munday (ORCID: https://orcid.org/0000-0002-1774-0529)
- Elizabeth M. Dauncey (ORCID: https://orcid.org/0000-0002-6953-5615)
- Tom D. Sheppard (ORCID: https://orcid.org/0000-0002-3455-1164)
Institutions
- AstraZeneca (Singapore) (SG)
- AstraZeneca (Poland) (PL)
- University College London (GB)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1021/acs.orglett.4c03468
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.75