Bondarzewia dickinsii Against Colitis-Associated Cancer Through the Suppression of the PI3K/AKT/COX-2 Pathway and Inhibition of PGE2 Production in Mice
In general, BD inhibited the onset and progression of CAC by modulating the composition of intestinal microbiota and metabolite levels, suppressing the PI3K/AKT/COX-2 pathway, and decreasing PGE2 expression. This study provides a significant reference for the development of BD as a dietary supplement and pharmaceutical agent in the treatment of CAC.
Authors
- Yangyang Han (ORCID: https://orcid.org/0000-0001-8458-7408)
- Lanzhou Li
- Junliang Chen (ORCID: https://orcid.org/0000-0001-9452-4697)
- Shuai Liu (ORCID: https://orcid.org/0000-0003-3229-4384)
- Xiaojing Dai
- Xin Zhang (ORCID: https://orcid.org/0000-0003-0047-3134)
- Yu Li (ORCID: https://orcid.org/0000-0002-7670-3998)
Institutions
- Chinese Academy of Sciences (CN)
- Jilin Province Science and Technology Department (CN)
- Tianjin Institute of Industrial Biotechnology (CN)
- Jilin Agricultural University (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2024-11-26
- DOI
- https://doi.org/10.3390/nu16234048
- Citations
- 1
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Natural Science Foundation of Jilin Province