Mechanism of miRNAs and miRNA-mRNA Regulatory Networks in Modulating Drug Resistance in HER2-Positive Breast Cancer: An Integrative Bioinformatics Approach
This integrative approach unveils a complex landscape of HER2 drug resistance in breast cancer, identifying crucial miRNAs, target genes, and significant pathways. The findings offer novel insights into the mechanisms governing drug resistance and highlight the potential for enhancing therapeutic strategies. Future studies are necessary for experimental validation to further explore the complex mechanisms involved.
Authors
- Sweta Rani (ORCID: https://orcid.org/0000-0003-0937-0094)
- Edel A. McNeela (ORCID: https://orcid.org/0000-0002-8700-3575)
- Jai Prakash Mehta (ORCID: https://orcid.org/0000-0002-4255-0516)
- Órla O’Donovan (ORCID: https://orcid.org/0000-0003-3980-8835)
- Thanh Hoa Vo
Institutions
- South East Technological University (IE)
- Institute of Technology Carlow (IE)
Publication Details
- Journal
- Cancers
- Published
- 2024-11-26
- DOI
- https://doi.org/10.3390/cancers16233962
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.57