Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs
Our findings confirm that the maternal haplogroup H, previously identified as protective against obesity in Kuwaiti Arabs, also serves as a protective factor against T2D in Arabs from the Gulf region. The study also identifies mitochondrial DNA variants that either increase or decrease the risk of T2D, underscoring their role in cellular energy metabolism.
Authors
- Sumi Elsa John (ORCID: https://orcid.org/0000-0001-6175-7005)
- Thangavel Alphonse Thanaraj (ORCID: https://orcid.org/0000-0002-4574-5343)
- Fahd Al‐Mulla (ORCID: https://orcid.org/0000-0001-5409-3829)
- Hussain Alsaleh (ORCID: https://orcid.org/0000-0001-8198-1645)
- Mohammed Dashti (ORCID: https://orcid.org/0000-0002-4797-430X)
- Rasheeba Nizam (ORCID: https://orcid.org/0000-0002-4762-9469)
- Naser M. Ali
Institutions
- Kuwait Petroleum Corporation (Kuwait) (KW)
- Dasman Diabetes Institute (KW)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-11-26
- DOI
- https://doi.org/10.3389/fendo.2024.1443737
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Kuwait Foundation for the Advancement of Sciences