Quantitative parameters of bone marrow segmentation on WB-DWI in the prognostic staging of R-ISS II multiple myeloma

Motivation: Revised International Staging System stage II multiple myeloma (R-ISS II MM) patients have considerable prognostic heterogeneity. Goal(s): Use quantitative parameters of bone marrow segmentation on whole-body diffusion-weighted imaging (WB-DWI) for risk stratification among R-ISS II MM patients. Approach: Univariate and multivariate analyses of clinical features and quantitative parameters of bone marrow segmentation extracted from MR Total Tumor Load software were used to identify predictors of progression-free survival and overall survival (OS). Results: On multivariate analysis, mean apparent diffusion coefficient (odds ratio=1.003, p=0.029, 95% confidence interval [95%CI]: 1.000-1.003) and albumin (odds ratio=0.942, p=0.051, 95%CI: 0.888-1.000) were independent predictors of OS. Impact: Quantitative parameters of bone marrow segmentation on WB-DWI can predict OS in R-ISS II MM patients, suggesting that these parameters can facilitate prognostic assessment of R-ISS II MM patients.