Utilizing Synthetic MRI and Amide Proton Transfer-Weighted MRI to Distinguish Malignant from Benign Sinonasal Lesions

Motivation: Distinguishing between benign and malignant sinonasal lesions is crucial for determining the appropriate treatment regimen and predicting patient outcomes. Goal(s): To evaluate the performance of synthetic MRI (SyMRI), combined with amide proton transfer (APT)-weighted MRI (APTw) in differentiating between malignant and benign sinonasal lesions. Approach: Eighty patients with sinonasal lesions were underwent the SyMRI and ATPw scan and the quantitative parameters were analyzed. Results: T1, T2, PD and APT values were significant between the benign and malignant groups. Combined SyMRI and APTw had the best diagnostic efficiency. Impact: Combined the SyMRI with APTw would function as a quantitative and contrast-free approach, significantly enhancing the differentiation of benign and malignant sinonasal lesions. This method also helps overcome the limitations associated with the superficial nature of nasal endoscopic sampling.