Differentiating Between Malignant and Benign Bone Tumors: Combined Diagnostic Value of DWI, IVIM and DKI

Motivation: The integration of various diffusion models can yield more precise insights into tumor diffusion and perfusion. Goal(s): To investigate the utility of combining DWI, IVIM and DKI in the differential diagnosis of benign and malignant bone tumors. Approach: Six parameters derived from three diffusion models of 107 patients were statistically compared through either the independent samples t-test or Mann-Whitney U test. Diagnostic performance was assessed using ROC curves for both individual examinations and their combined analysis in distinguishing between benign and malignant tumors. Results: The combination of ADC, D, D*, MK, and MD values had better diagnostic efficacy than these parameters alone. Impact: Statistically significant differences were observed in the values of ADC, D, D*, MD, and MK between benign and malignant bone tumors. Furthermore, the combination of ADC, D, D*, MK, and MD values had better diagnostic efficacy than these parameters alone.