Assessing Cross-Site Variability in 129Xe Spectroscopy Measurements Across Major Scanner Platforms
Motivation: Hyperpolarized 129Xe gas exchange magnetic resonance spectroscopy (MRS) lacks standardized healthy reference values. Goal(s): To standardize 129Xe gas exchange MRS biomarker reference values across different MRI systems and estimate a T2* for consistent analysis of 129Xe gas exchange MRI. Approach: Healthy 18-30 yr old non-smokers underwent 129Xe MRS using the consortium recommended protocol across three research centers and three different MRI vendors. Results: Findings indicated consistent RBC-to-membrane ratios across sites but slight differences in RBC shifts, oscillation amplitudes, and T2* values. Impact: Establishing healthy reference values for multi-site 129Xe spectroscopy will facilitate its incorporation into collaborative respiratory research.
Authors
- Juan Parra‐Robles (ORCID: https://orcid.org/0000-0002-8215-0816)
- Junlan Lu (ORCID: https://orcid.org/0000-0001-5023-7901)
- Andrew D. Hahn (ORCID: https://orcid.org/0000-0002-0246-2108)
- Sean B. Fain (ORCID: https://orcid.org/0000-0001-5461-0646)
- Zackary I. Cleveland (ORCID: https://orcid.org/0000-0001-6195-9061)
- David Mummy (ORCID: https://orcid.org/0000-0001-7885-109X)
- Aryil Bechtel (ORCID: https://orcid.org/0000-0002-2928-3898)
- Suphachart Leewiwatwong
- Bastiaan Driehuys (ORCID: https://orcid.org/0000-0002-1236-4210)
- Matthew M. Willmering (ORCID: https://orcid.org/0000-0002-4356-9622)
- Shuo Zhang (ORCID: https://orcid.org/0000-0001-8171-2779)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/5084
- Primary Topic
- Atomic and Subatomic Physics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00