Resting-state fMRI network efficiency mediates the association between glymphatic system and cognition function in OSAHS: a DTI-ALPS study

Motivation: Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) is a serious sleep disorder linked to cognitive impairment. This study investigates the glymphatic system's role in OSAHS and its impact on cognition. Goal(s): Explore glymphatic system changes in OSAHS and their influence on cognitive function. We aim to uncover the mechanisms connecting OSAHS and cognitive issues. Approach: We use DTI-ALPS and rs-fMRI to assess the glymphatic system and brain network properties. Correlations and mediation analysis examine the link between glymphatic function, cognitive abilities, and OSAHS severity. Results: OSAHS patients exhibit reduced glymphatic function, affecting cognitive performance. Impact: This study may enhance comprehension of cognitive problems in OSAHS, suggesting dementia risk. It could inform early intervention, enhancing OSAHS patients' quality of life.