Multifunctional Nanocomposite for Enhanced Diagnosis and Therapeutic Intervention in Breast Cancer via T1-T2 dual-enhanced and NIR II imaging

Motivation: Breast cancer exhibits high incidence and mortality rates. We reports a functional nanosystem composed of Pluronic F127, manganese chloride (MnCl2), and IR780 dye. The nanosystem possesses multimodal imaging capabilities using near-infrared II (NIR-II) and T1-T2 dual-enhanced MRI, guiding photothermal therapy, and enhancing the STING pathway to combat triple-negative breast cancer. Goal(s): Effectively suppress TNBC growth and metastasis, with good biocompatibility.. Approach: MC@NS nanosystem could diagnose the tumor and confirm the time window of treatment via NIR II/MRI dual-modal imaging, and effectively suppress tumor growth thought phototherapy, STING pathway and anti-tumor immunity. Results: It effectively suppress tumor growth thought phototherapy, STING pathway and immunotherapy. Impact: This nanosystem, through T1-T2 dual-enhanced MRI and NIR II multimodal imaging, enabled tumor diagnosis and guided photothermal therapy, effectively suppressing tumor growth by combining photothermal therapy and STING pathway to enhance immunogenic cell death, providing a novel theranostic strategy.