A combined T2* weighted gradient echo and 1D quantitative flow sequence for investigating placental function

Motivation: Both oxygenation and blood flow are key measures of placental function; if we could dynamically, and simultaneously measure T2* and flow we could investigate placental function over time. Goal(s): To Implement and test a gradient echo, quantitative flow sequence with EPI readout in the placenta. Approach: 4 participants were scanned at 3T using the sequence, and the T2* and velocity maps produced were investigated. Results: The T2* weighted image retained sufficient contrast, and the quantitative flow was repeatable across subjects, measuring similar velocities in the placenta (<0.1cm/s) that has previously been measured with MRI. Impact: This sequence has promise for dynamically investigating placental function, simultaneously providing information about oxygenation and blood flow. This will allow us to evaluate placental function in compromised pregnancies over time, and investigate the role of placental contractions.