Identification of cortical locations functionally connected to the hippocampus for personalized multi-target TMS neuromodulation

Motivation: Personalized TMS targeting based on functional connectivity has been proposed. However, the dispersion of personalized TMS targets remains unknown. Goal(s): Characterize brain areas functionally connected to the hippocampus in a population. Approach: Identify hippocampus-based memory networks using the resting-state fMRI data from the Human Connectome Project. Results: The medial prefrontal cortex (mPFC) and lateral parietal cortex (PPC) were found to be connected to the hippocampus. The centroids of group-average results were separated from the atlas coordinates by about 11 mm. Individualized targets are dispersed around the group-average coordinates (mPFC: 11.1 +/- 3.8; PPC: 3.4 +/- 2.3 mm). Impact: The functional connectivity analysis on the Human Connectome Project resting-state fMRI data with the seed at the hippocampus revealed that the medial prefrontal cortex (mPFC) and lateral parietal cortex (PPC) connected to the hippocampus significantly dispersed across individuals.