MRI study of enlarged choroid plexus in patients with spinocerebellar ataxia type 3.
Motivation: The role of cerebral immune and homeostatic structures of choroid plexus (CP) in SCA3 patients remains elusive. Goal(s): The objective of this study is to investigate the volumetric changes in the choroid plexus. Approach: Whole brain of SCA3 patients was imaged using a 3T MRI scanner and the volume of CP was analyzed. Results: The findings revealed that CP volume was significantly larger in the SCA3 group compared to normal control group, exhibiting a positive correlation with both the number of ATXN3 repeats and scores of motor function abnormalities. Impact: The abnormal change of CP volume may serve as a new marker for distinguishing SCA3 patients
Authors
- Zhentao Zuo (ORCID: https://orcid.org/0000-0002-5909-3884)
- Zhiming Zhen (ORCID: https://orcid.org/0009-0000-2153-5213)
- Chen Liu (ORCID: https://orcid.org/0000-0001-5149-2496)
- Yang Hua (ORCID: https://orcid.org/0000-0002-4159-5237)
- Wei Chen (ORCID: https://orcid.org/0000-0002-9600-1336)
- Chenghao Cao (ORCID: https://orcid.org/0000-0002-4625-5020)
- Yonghua Huang (ORCID: https://orcid.org/0000-0002-0366-9768)
- Peiling Ou
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0033
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00