Kidney MR Fingerprinting and Arterial Spin Labeling (ASL) Assessments of Autosomal Recessive Polycystic Kidney Disease (ARPKD)
Motivation: There are no clinically available therapies for ARPKD. Goal(s): We evaluated the ability of T1 and T2 from MR Fingerprinting (MRF) to assess kidney cystic burden and Arterial Spin Labeling (ASL) to assess kidney perfusion to detect and stage ARPKD kidney disease. Approach: 12 ARPKD patients and 10 healthy adult volunteers were scanned on a Siemens 3T with kidney MRF and ASL MRI methods to generate kidney cortical perfusion maps. Results: Significant increases in kidney T1 and T2, and reduced perfusion were observed between ARPKD patients and healthy volunteers (p<0.001) and between ARPKD patients with early and mild-to-moderate CKD based on eGFR (p<0.03). Impact: The multi-modal MRI biomarkers in combination evaluated were able to distinctly stratify all three cohorts, including the two ARPKD patient cohorts, demonstrating the utility of a multi-modal MRI approach during future clinical trials aimed at limiting ARPKD kidney disease progression.
Authors
- Ashlee Parsons (ORCID: https://orcid.org/0000-0001-6859-3373)
- Jenna Hach
- Yuran Zhu (ORCID: https://orcid.org/0000-0003-2829-7451)
- Susan Farr (ORCID: https://orcid.org/0000-0001-7930-6341)
- Chris A. Flask (ORCID: https://orcid.org/0000-0002-1066-333X)
- Michael Markley (ORCID: https://orcid.org/0000-0002-8710-4405)
- Mireia Perera-Gonzalez (ORCID: https://orcid.org/0000-0003-1033-295X)
- Jacob R. Perino (ORCID: https://orcid.org/0000-0003-3958-5432)
- Christina J. MacAskill (ORCID: https://orcid.org/0000-0003-0023-0044)
- Dan Ma (ORCID: https://orcid.org/0000-0003-1664-9579)
- Heather A. Clark (ORCID: https://orcid.org/0000-0002-2628-9194)
- Nicole Pritts (ORCID: https://orcid.org/0000-0002-4732-4243)
- Stephanie Larson (ORCID: https://orcid.org/0000-0001-6338-8725)
- Madison Kretzler (ORCID: https://orcid.org/0000-0002-2619-2894)
- Bernd Kuehn (ORCID: https://orcid.org/0000-0003-1263-5946)
- Yong Chen (ORCID: https://orcid.org/0000-0001-6183-2693)
- Xin Yu (ORCID: https://orcid.org/0000-0001-8996-0267)
- Victoria Gange
- Ke Cheng Liu
- Katherine M. Dell
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2891
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00