Imaging brain metabolic alterations of multiple sclerosis using fast high-resolution 3D-CRT-MRSI at 7T

Motivation: MR spectroscopy offers biomarkers like myo-inositol and N-acetylasparate that can better predict disability progression and clinical status in multiple sclerosis. However, traditional MR spectroscopic imaging faces challenges like limited resolution and lengthy acquisition times, hampering its clinical utility. Goal(s): This study aimed to assess a novel 7T 3D-concentric-ring-trajectory-readout MRSI, addressing these limitations, for reliable metabolic marker imaging in MS. Approach: Metabolic images were obtained from 26 MS patients and compared with 13 healthy controls. Results: Altered brain metabolism in MS was effectively visualized across a large brain volume, revealing significant differences in metabolite levels within normal-appearing white matter. Impact: We showcase extensive, high-resolution brain metabolic mapping of multiple sclerosis within a clinically viable timeframe. This can enhance disease monitoring and improve the assessment of treatment effectiveness.

Authors

Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2024-11-26
DOI
https://doi.org/10.58530/2024/0255
Primary Topic
Advanced MRI Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00
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article

Imaging brain metabolic alterations of multiple sclerosis using fast high-resolution 3D-CRT-MRSI at 7T

Eva Niess, Siegfried Trattnig, Wolfgang Bogner, Stanislav Motyka et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Advanced MRI Techniques and Applications
article

Imaging brain metabolic alterations of multiple sclerosis using fast high-resolution 3D-CRT-MRSI at 7T

Eva Niess, Siegfried Trattnig, Wolfgang Bogner, Stanislav Motyka, Lukas Hingerl, Paulus Stefan Rommer, Alexandra Lipka, Fabian Niess, Gilbert Hangel, Bernhard Strasser, Anna Petrova, Assunta Dal‐Bianco
article en

Abstract

Motivation: MR spectroscopy offers biomarkers like myo-inositol and N-acetylasparate that can better predict disability progression and clinical status in multiple sclerosis. However, traditional MR spectroscopic imaging faces challenges like limited resolution and lengthy acquisition times, hampering its clinical utility. Goal(s): This study aimed to assess a novel 7T 3D-concentric-ring-trajectory-readout MRSI, addressing these limitations, for reliable metabolic marker imaging in MS. Approach: Metabolic images were obtained from 26 MS patients and compared with 13 healthy controls. Results: Altered brain metabolism in MS was effectively visualized across a large brain volume, revealing significant differences in metabolite levels within normal-appearing white matter. Impact: We showcase extensive, high-resolution brain metabolic mapping of multiple sclerosis within a clinically viable timeframe. This can enhance disease monitoring and improve the assessment of treatment effectiveness.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Good health and well-being
Openalex Percentile: Top 62%
Advanced MRI Techniques and Applications
DOISourceOpenAlex
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Imaging brain metabolic alterations of multiple sclerosis using fast high-resolution 3D-CRT-MRSI at 7T — Eva Niess, Siegfried Trattnig, et al. · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2024) | TGRS Research Map | TGRS