Diagnostic value of modified clear cell likelihood score based on pseudocapsule for predicting the malignancy in small renal masses

Motivation: Clear cell likelihood score version 2.0 (ccLS v2.0) is not yet able to predict malignancy in small renal masses (SRMs). Pseudocapsule may provide added value with ccLS v2.0Goal(s): To develop a modified clear cell likelihood score based on pseudocapsule (m-ccLS) for predicting malignancy in SRMsApproach: Receiver operating characteristic curve (ROC), net reclassification index (NRI), and integrated discrimination improvement (IDI) were used to compare diagnostic value of m-ccLS and ccLS v2.0Results: Area under curve (AUC), NRI and IDI of m-ccLS were superior to those of ccLS v2.0 for the diagnosis of malignancy. The likelihood of malignancy increased with higher m-ccLS scoresImpact: M-ccLS achieved predict malignancy of small renal masses (SRMs). M-ccLS may be a valuable tool for expanding the clinical application of this scoring system and contributing to its further promotion and dissemination