Fetal MRI-based body and adiposity quantification for small for gestational age perinatal risk stratification
Motivation: Small for gestational age (SGA) fetuses are undernourished and at higher risk for adverse outcomes; however, conventional assessment methods exhibit limited sensitivity. Goal(s): To stratify perinatal risk using MRI-based body composition metrics. Approach: TruFISP and 2-points Dixon images were used to compute the total fetal volume (TFV), fat-to-body volume ratio (FBVR) and adipose tissue fat signal fraction (FSF) using deep-learning segmentation. Results: SGA fetuses (N=40) with lower FBVR were more likely to require obstetric interventions because of non-reassuring status, while those with reduced TFV were prone to adverse neonatal outcomes. The model’s sensitivity/specificity rates are 85.7%/87.5% and 82.35%/86.4%, respectively. Impact: Quantifying fetal body composition through MRI can offer additional insights into the severity of small for gestational age complicated pregnancies and may help in stratifying perinatal risk.
Authors
- Bella Specktor‐Fadida (ORCID: https://orcid.org/0000-0002-5668-0303)
- Bossmat Yehuda (ORCID: https://orcid.org/0000-0002-5506-1498)
- Aviad Rabinowich (ORCID: https://orcid.org/0000-0002-9406-6523)
- Leo Joskowicz (ORCID: https://orcid.org/0000-0002-3010-4770)
- Jacky Herzlich (ORCID: https://orcid.org/0000-0001-8999-6841)
- Dafna Ben Bashat (ORCID: https://orcid.org/0000-0001-8396-1031)
- Yair Wexler (ORCID: https://orcid.org/0000-0002-6270-3188)
- Bar Neeman (ORCID: https://orcid.org/0009-0008-4806-2979)
- Liat Ben‐Sira (ORCID: https://orcid.org/0000-0002-0827-0190)
- Karina Krajden Haratz (ORCID: https://orcid.org/0000-0001-9868-3548)
- Liran Hiersch (ORCID: https://orcid.org/0000-0003-4443-388X)
- A. Zilberman (ORCID: https://orcid.org/0000-0002-7860-2605)
- Netanell Avisdris (ORCID: https://orcid.org/0000-0002-0719-1327)
- Dafna Link‐Sourani
- Tamir Graziani
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/0006
- Citations
- 2
- Primary Topic
- Fetal and Pediatric Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.11