Towards precise quantification of chronic active MS lesions using submillimeter isotropic QSM with 3D-EPI at 3T
Motivation: Quantitative susceptibility mapping (QSM) enables in vivo detection of chronic active brain lesions in Multiple Sclerosis (MS) due the presence of iron-laden lesion borders also called Paramagnetic Rim Lesions (PRL). Goal(s): To evaluate the feasibility of generating submillimeter isotropic resolution QSM using 3D-EPI for precise quantification of PRL in MS patients. Approach: Separate masks for the lesion rim and lesion core were generated. Results: Submillimeter resolution reduces the partial volume averaging effect and enables measurement of the lesion rim in PRL+ lesions, which exhibit susceptibility values 3 times that of the lesion core. Impact: This study demonstrates the feasibility of submillimeter isotropic quantitative susceptibility mapping to precisely quantify the magnetic susceptibility properties of MS lesions.
Authors
- Jin Jin (ORCID: https://orcid.org/0000-0002-8671-317X)
- M. Marcel Maya (ORCID: https://orcid.org/0000-0003-4097-8639)
- Nader Binesh
- Omar Al‐Louzi (ORCID: https://orcid.org/0000-0003-2260-5660)
- Brian Renner (ORCID: https://orcid.org/0000-0003-3729-5255)
- Fei Han (ORCID: https://orcid.org/0000-0002-6178-5118)
- Nancy L. Sicotte (ORCID: https://orcid.org/0000-0002-5131-3352)
- Marwa Kaisey (ORCID: https://orcid.org/0000-0001-6019-7317)
- Mustafa Subhi (ORCID: https://orcid.org/0009-0009-3448-7930)
- Debiao Li (ORCID: https://orcid.org/0000-0001-8560-8231)
- Pascal Sati
- Bryan Quah (ORCID: https://orcid.org/0009-0009-9641-3363)
- Sreekanth Madhusoodhanan Nair (ORCID: https://orcid.org/0000-0003-3549-3848)
- Elaina Gombos (ORCID: https://orcid.org/0009-0008-6482-737X)
- Arzu Has Silemek
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2024-11-26
- DOI
- https://doi.org/10.58530/2024/2936
- Primary Topic
- Biosensors and Analytical Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00